Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities

J M Jacyno; J S Harwood; N H Lin; J E Campbell; J P Sullivan; M W Holladay

doi:10.1021/np960352c

Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities

J Nat Prod. 1996 Jul;59(7):707-9. doi: 10.1021/np960352c.

Authors

J M Jacyno¹, J S Harwood, N H Lin, J E Campbell, J P Sullivan, M W Holladay

Affiliation

¹ College of Pharmacy, Ohio Northern University, Ada 45810, USA.

PMID: 8759171
DOI: 10.1021/np960352c

Abstract

The norditerpenoid alkaloid lycaconitine (2) was synthesized from lycoctonine (3) and its affinity determined for two neuronal nicotinic acetylcholine receptor subtypes. The structure of 2 was confirmed by a combination of spectroscopic methods.

MeSH terms

Alkaloids / chemical synthesis
Alkaloids / chemistry
Alkaloids / pharmacology*
Animals
Binding, Competitive / drug effects
Brain Chemistry / drug effects
In Vitro Techniques
Magnetic Resonance Spectroscopy
Membranes / drug effects
Membranes / metabolism
Neurons / drug effects
Neurons / metabolism*
Rats
Receptors, Nicotinic / drug effects
Receptors, Nicotinic / metabolism*
Spectrophotometry, Infrared

Substances

Alkaloids
Receptors, Nicotinic
lycaconitine